ステークカジノ(Stake)とは？評判口コミや入金不要ボーナス・ ...

Fields Medical Life Sciences Information Communication Environment Nanotechnology / Materials Energy Manufacturing Technology Social Infrastructure Frontier Liberal Arts Themes Researchers JP Top Medical Development of the next generation anti-HIV agents Development of the next generation anti-HIV agents JAPANESEINQUIRY update：2024/01/23     NEXT PREV Features and Uniqueness HIV infection is one of most serious concern in infectious diseases. We will perform anti-HIV assays for unmet medical needs in control of HIV infections with established novel assays. We have developed reverse transcriptase inhibitor that has novel mechanism of inhibition, translocation-inhibition (J Biol Chem, 2009). Dr Kodama participated in the primary screening and development of a new HIV integrase inhibitor, elvitegravir (J Virol 2009), and a unique reverse transcriptase inhibitor, islatravir, which phase III clinical trials by the Merck & Co., Inc. will complete, soon. We have a representative resistant HIV strain-library for anti-HIV screening and several target oriented high through-put screening systems. Practical Application We can establish high through-put screening for new targets, so please consult with us individually. We are open to joint development requiring BSL3/P3 experimental facilities and academic guidance including other microorganisms. Keywords HIV anti-viral screening evaluation inhibitors viruse Researchers International Research Institute of Disaster Science Eiichi Kodama, ProfessorMD, PhD Laboratory Website researchmap Laboratory Website researchmap Related Information 1 Asai et al. Use of a biosynthetic intermediate to explore the chemical diversity of pseudo-natural fungal polyketides. Nature Chemistry 7:737-743, 2015 2 Salie et al. Structural basis of HIV inhibition by translocation-defective RT inhibitor 4’-ethynyl-2-fluoro-2’-deoxyadenosine (EFdA). Proceedings of National Academy of Science of the United States of America 113:9274–9279, 2016 3 Watanabe et al. A novel peptide derived from the fusion protein heptad repeat inhibits replication of subacute sclerosing panencephalitis virus in vitro and in vivo. PLOS ONE 11: e0162823, 20164 Oe et al. Pyrimidine analogues as a new class of gram-positive antibiotics, mainly targeting thymineless-death related proteins. ACS Infectious Diseases 6:1490–1500, 20205 Tsukada et al. Synthetic biology-based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones. Nature Communications 11, Article number: 1830, 20206 Nakagawara et al. Application of human lymphoid cells for the evaluation of antivirals against human adenovirus type 19: Zalcitabine has superior activity compared to cidofovir. Antiviral Chemistry and Chemotherapy 28:1-5, 2020 doi:10.1177/20402066209213197 Ohata et al. Antiviral Activity and Resistance Profile of the Novel HIV-1 Non-Catalytic Site Integrase Inhibitor, JTP-0157602. Journal of Virology 96:e01843-21. doi: 10.1128/JVI.01843-218 Makino et al. Serine hydroxymethyltransferase as a potent target of antibacterial agents acting synergistically with one-carbon metabolism-related inhibitors. Communications Biology 2022 in printing Browsing History Same Researcher Development and evaluation of various inhibitors and disinfectants for SARS-CoV-2 [ 児玉 栄一 教授 ] Common Keywords Lymph node metastasis prediction and treatment evaluation system [ 小玉 哲也 教授 ] Gastroenteritis virus-binding enteric bacteria for probiotics [ 佐野 大輔 教授 ] User Who Reviewed This Content Also Reviewed Extracorporeal Shock Wave Therapy as a New, Non-Invasive Angiogenic Therapy [ SHIMOKAWA Hiroaki Professor ] Molecular Imaging from Basic Research to Clinical Application [ YANAI Kazuhiko Professor ] Noninvasive Ultrasonic Measurement of Dynamic Properties of Heart and Arteries [ Hiroshi Kanai Professor ] Research Profiles ©TOHOKU UNIVERSITY How to Use FAQ For Researchers Site Policy [jp] ©TOHOKU UNIVERSITY Fields Medical Life Sciences Information Communication Environment Nanotechnology / Materials Energy Manufacturing Technology Social Infrastructure Frontier Liberal Arts Fields Themes Researchers 日本語 ENGLISH Close