オンカジハイローラー

This site uses Google Analytics to monitor site usage.Google Analytics uses COOKIEs to collect user information. View our COOKIE policy. Do not acceptAcceptGo To ContentHomeNewsEventsThemesAccessDonateJASearch MenuHomeHomeWho we areWho we areAbout usAbout usAbout usAcademic CalendarMessage from the PresidentQuestionnaireSite PolicyOfficial social media accountsThe UniversityFacts and FiguresVisionVisionVisionOur visionResearch: Working with society, for societyEducation: Thinking globallyInternational: Hub campusLocal Partnerships: Training for the futurePartner UniversitiesInternational OfficesInitiatives for SDGsThe Kobe University FundOur HistoryOur HistoryOur HistoryOur HistoryThe Kobe University FundThe Kobe University FundThe Kobe University FundThe Kobe University FundOrganization and University AdministrationOrganization and University AdministrationOrganization and University AdministrationExecutive membersContactKobe University DirectoryRules and RegulationsChartersChartersChartersCharter on EducationCharter on EnvironmentCharter on ResearchPublic RelationsPublic RelationsPublic RelationsPublic RelationsPublications - Back numbersPress Release ProcedureInformation DisclosureInformation DisclosureInformation DisclosureInternational ProgramsDistinctive Education and Research ProgramsCertified Evaluation and AccreditationLong-term Plan and Evaluation of the UniversityMission and GoalAcademic OrganizationTeaching StaffStudentsCurriculum, Standard for Grading System, Criteria for Graduation Completion of CourseEducation and Research Environments for StudentsTuition and FeesStudent SupportInternational ActivitiesStudying in JapanFor International StudentsUniversity Information and DisclosureCampusCampusCampusCampusStudy in KobeStudy in KobeAdmissionsAdmissionsAdmissionsAbout admissionsAdmission Policy of Kobe UniversityUndergraduate AdmissionsGraduate School Admissions - Master's programmesGraduate School Admissions - Doctoral programmesResearch StudentsExchange programsCourses in EnglishCourses in EnglishCourses in EnglishEnglish-Based Master's Program (MA, Graduate School of Science)ICHS Course (MA, PhD, Graduate School of Health Sciences)International Program for Medical Research (PhD, Graduate School of Medicine)Kobe Global Graduate Program for Agricultural Science (MA, PhD, Graduate School of Agricultural Science)Kobe University Interdisciplinary Master Program (KIMAP)SESAMI PhD Program (PhD, Graduate School of Business Administration)Special Course on Development Policy (MA, Graduate School of International Cooperation)CoursesCoursesCoursesAgricultural Engineering and Socio-Economics (Bachelor)Agricultural Engineering and Socio-Economics (Doctoral)Agricultural Engineering and Socio-Economics (Master)Agrobioscience (Bachelor)Agrobioscience (Doctoral)Agrobioscience (Master)Architecture (Bachelor)Architecture (Doctoral)Architecture (Master)Biology (Bachelor)Biology (Doctoral)Biology (Master)Biomedical Sciences (Master)Bioresource Science (Bachelor)Bioresource Science (Doctoral)Bioresource Science (Master)Business Administration (Bachelor)Business Administration (Doctoral)Business Administration (Master)Chemical Science and Engineering (Bachelor)Chemical Science and Engineering (Doctoral)Chemical Science and Engineering (Master)Chemistry (Bachelor)Chemistry (Doctoral)Chemistry (Master)Child Education (Bachelor)Computational Science (Doctoral)Computational Science (Master)Cultural Interaction (Doctoral)Cultural Interaction (Master)Culture and Globalization (Doctoral)Culture and Globalization (Master)Development and Economics Program (Doctoral)Development and Economics Program (Master)Economics (Bachelor)Economics (Doctoral)Economics (Master)Engineering, Civil (Bachelor)Engineering, Civil (Doctoral)Engineering, Civil (Master)Engineering, Computer and Systems (Bachelor)Engineering, Electrical and Electronic (Bachelor)Engineering, Electrical and Electronic (Doctoral)Engineering, Electrical and Electronic (Master)Engineering, Mechanical (Bacheloar)Engineering, Mechanical (Doctoral)Engineering, Mechanical (Master)Environment and Sustainability (Bachelor)Global Cultures (Bachelor)Global Transportation Sciences (Bachelor)Health Sciences (Bachelor)Health Sciences (Doctoral)Health Sciences (Master)Human Cultural Studies (Doctoral)Human Cultural Studies (Master)Human Development and Community (Bachelor)Human Development (Doctoral)Human Development (Master)Human Environmental Science (Doctoral)Human Environmental Science (Master)Human Social Dynamics (Doctoral)Human Social Dynamics (Master)Humanities (Bachelor)Information Science (Doctoral)Information Science (Master)International Law/Law and Development Program (Doctoral)International Law/Law and Development Program (Master)International Studies Program (Doctoral)International Studies Program (Master)Kobe University Interdisciplinary Master Program (KIMAP)Law (Bachelor)Law and Politics (Law - Master)Law and Politics (Law - Doctoral)Law and Politics (Political Science - Doctoral)Law and Politics (Political Science - Master)Marine Engineering (Bachelor)Maritime Sciences (Doctoral)Maritime Sciences (Master)Mathematics (Bachelor)Mathematics (Doctoral)Mathematics (Master)Medical Sciences (Doctoral)Medicine (Bachelor)Ocean Safety Systems Science (Bachelor)Physics (Bachelor)Physics (Doctoral)Physics (Master)Planetology (Bachelor)Planetology (Doctoral)Planetology (Master)Political Science and Area Studies Program (Doctoral)Political Science and Area Studies Program (Master)Science, Technology and Innovation (Doctoral)Science, Technology and Innovation (Master)Systems Science (Doctoral)Systems Science (Master)Short Term ProgramsShort Term ProgramsShort Term ProgramsShort Term ProgramsAcademic PolicyAcademic PolicyAcademic PolicyDiploma PolicyCurriculum PolicyStudy in JapanStudy in JapanStudy in JapanStudy in JapanProcedures for Entering JapanChange of Status of ResidenceExtension of Period of StayImmigration and Residence Procedures upon Arrival in JapanInviting Family Members to Japan and Necessary Procedures after their ArrivalLeaving Japan temporarily and Re-entryOrientation for New International StudentsWork Permit for Part-time JobsProcedure for Staying in JapanResidence Card ReissuanceInformation to report to the Immigration BureauResidence CardTemporary Withdrawal from UniversityCampus LifeCampus LifeAbout Kobe and HyogoAbout Kobe and HyogoAbout Kobe and HyogoAbout Hyogo PrefectureAbout Kobe CityTop 5 Must-see Attractions in KobeCampus GuideCampus GuideCampus GuideKobe University CafeteriasRegistered Tangible Cultural Properties in Kobe UniversityFacilities for Fitness and Extracurricular ActivitiesKobe University Medical Center for Student HealthInformation Science and Technology CenterKobe University Learning CommonsLearning Facilities and Relaxing EnvironmentsKobe University LibrariesStudent LifeStudent LifeStudent LifeClubs and Circles in Kobe UniversityDaily lifeStudent voicesAcademic CalendarAcademic CalendarAcademic CalendarAcademic CalendarTuition and FeesTuition and FeesTuition and FeesAbout TuitionAbout Enrollment Fee Exemption and DeferralAbout Tuition Fee ExemptionEnrollment Fee Exemption and Deferral Tuition Fee ExemptionStudent SupportStudent SupportStudent SupportStudent SupportHousing InformationHousing InformationHousing InformationHousing InformationKobe University Residential FacilitiesPrivate Dormitories and ResidencesRental Guarantor System at Kobe UniversityWhen moving outPrivate HousingScholarshipsScholarshipsScholarshipsScholarshipsPre-enrollment ScholarshipsCareersCareersCareersCareersInternshipsKobe University Tokyo Office - Career Centre, Tokyo BranchAlumniAlumniAlumniOverseas Alumni AssociationsKobe University Homecoming DayKobe University Community Network "KU-Net"Notice regarding the issuing of various certificates for graduatesResearch andCorporate RelationsResearch andCorporate RelationsResearch SupportResearch SupportResearch SupportResearch SupportAccommodationGrant Application Support in EnglishHandbook for international researchersSupport schemeCode of Conduct for ScientistsFunded Research ProgramsFunded Research ProgramsFunded Research ProgramsFunded Research ProgramsGrants-in-Aid for Scientific ResearchKobe University Strategic International Collaborative Research GrantDevelopment of a global-standard, minimally invasive, functional brain network mapping technique for brain surgeryEstablishing an Asian Network to develop a novel treatment for prostate cancerInternational consortium on ‘Mie-tronics’: a new emerging field of nanophotonicsInternational agricultural research platform for sustainable food productionIlluminating how huge earthquakes occur in Japan, Mexico and ChileCreating an international innovation hub for engineering biologyInternational membrane consortium on research and education strives for sustainable and carbon-neutral societiesInstitute of Promoting Academic Research ProgramsInstitute of Promoting Academic Research ProgramsInstitute of Promoting Academic Research ProgramsInstitute of Promoting Academic Research ProgramsOffice of Research ManagementOrganization for Advanced and Integrated ResearchResearch Facility Center for Science and TechnologyCollaborationCollaborationCollaborationCollaborationEnterprise Partnerships DivisionOffice of Promoting Regional PartnershipFaculties and SchoolsFaculties and SchoolsNewsNewsCategoryFeaturesInterviewsProjectsSpecial issuesPress releasesSDGsGoal 1: No povertyGoal 2: Zero hungerGoal 3: Good health and well-beingGoal 4: Quality educationGoal 5: Gender equalityGoal 6: Clean water and sanitationGoal 7: Affordable and clean energyGoal 8: Decent work and economic growthGoal 9: Industry, Innovation and InfrastructureGoal 10: Reduced inequalityGoal 11: Sustainable cities and communitiesGoal 12: Responsible consumption and productionGoal 13: Climate actionGoal 14: Life below waterGoal 15: Life on landGoal 16: Peace, justice and strong institutionsGoal 17: Partnership for the goalsAreasSocial sciencesMathematics and physicsChemistryEngineering sciencesInformaticsBiological sciencesAgriculture and EnvironmentMedicine, dentistry and pharmacologyHumanitiesEventsEventsEvent categoriesTalksOpen lecturesUniversity activitiesEvent areasSocial sciencesEvent locationsRokkodai 1st CampusOff-campusOnlineEvent audiencesStudentsAudienceProspective studentsCurrent studentsAlumsCorporate and societyFaculty and staff CloseNews TopCategoriesPress releasesRead in日本語2016.11.25New method for predicting congenital CMV infection during the prenatal period Medicine, dentistry and pharmacologyObstetrics and gynecologyEmbryonic medicine / PediatricsInfectious diseasesCytomegalovirusesBacteria / VirusesTesting / Diagnosis (medicine)Congenital cytomegalovirus (CMV) infection can cause serious complications such as hearing difficulties and mental retardation in affected infants. A Japanese research team has discovered a new method for predicting congenital CMV infection during the prenatal period. This method is safe for both mothers and fetuses, and could potentially be adopted for general use. The findings were published on October 20 in the online version of Clinical Infectious Diseases.Research team members include Professor YAMADA Hideto (Kobe University Graduate School of Medicine, Department of Obstetrics and Gynecology), Associate Professor TANIMURA Kenji (Kobe University Hospital Center for Perinatal Care), Project Professor MORIOKA Ichiro (Graduate School of Medicine, Department of Pediatrics) and Doctor MINEMATSU Toshio (Director of the Aisenkai Nichinan Hospital Research Center for Disease Control).In the United States over 8000 children a year suffer from the long-term complications of congenital CMV infection, and the annual costs of caring for these children are estimated at 1-2 billion dollars. In recent years, some doctors have successfully combated these problems by using antiviral agents to treat infants with congenital CMV infection. To facilitate this, early diagnosis is vital. However, tests to identify the infection in infants (PCR tests that detect virus DNA in infants’ urine) are not widely carried out, and would incur huge financial costs if they were carried out for all infants. Currently the most realistic and financially viable approach is targeting pregnant women who have a high risk of congenital infection and testing their newborn infants with a PCR urine examination.As shown in figure 1, congenital infection usually occurs when women who lack antibodies for CMV contract the virus for the first time during pregnancy (primary CMV infection). Pregnant women at high risk for congenital infection are generally identified by testing for the CMV antibody immunoglobulin M (IgM). There are often cases of women who test positive for CMV IgM antibodies during pregnancy, but in some cases tests remain positive for CMV IgM for several years after primary infection, which may cause pregnant women and their family undue worry. The most accurate method for detecting fetal infection during pregnancy is testing for viral DNA in amniotic fluid. However, the amniotic fluid sampling is an invasive procedure that can result in rupture of the membranes, uterine infection, or miscarriage. The research team looked for a non-invasive method of predicting congenital CMV in fetuses.They surveyed 300 pregnant women who tested positive for CMV antibodies (IgM) and were classified as high-risk for congenital injection. They carried out clinical interviews, blood tests, ultrasounds, and DNA PCR tests for CMV using samples of the subjects’ blood, urine and uterine cervical secretion. The medical interviews tested whether the women had cold-like symptoms, the blood test included measuring white blood cell count, viral antigens, and an IgG activity test (to determine whether subjects had recent CMV infection), and the ultrasound examinations looking for symptoms of congenital CMV infection in the fetus. They also tested the women’s blood, urine and uterine cervical secretion for CMV DNA.After statistical analysis of all the results, the team determined that fetal abnormalities revealed through ultrasound and positive PCR results for uterine cervical secretion were the two most effective ways to predict congenital infection before birth. This is the first report to demonstrate that uterine cervical secretion can be used to predict congenital CMV infection.Both ultrasound and PCR tests for uterine cervical secretion are non-invasive procedures, and using them can offer a safer method to test high-risk pregnant women and predict the occurrence of congenital infection. Accurately identifying the affected infants enables doctors to start antiviral treatment early, and could improve the neurological prognosis of infants infected by CMV.Figure 1. Mother-to-child transmission of CMV and potential disabilities30% of pregnant women do not have CMV antibodies. 1% of this group will contract CMV for the first time during pregnancy. Among them, 40% of women will have viral transmission to fetuses. Even if the fetus contracts the virus, the infant will not necessarily suffer subsequent complications. One-fifth of infected infants are born with apparent symptoms, and 90% of this group will have sequelae. 80% of infected infants will not have apparent symptoms, but one-tenth of this group develop sequelae. Even if the woman has CMV antibodies before pregnancy, there is a low incidence of the virus reactivating and affecting the fetus.Figure 2. Venn diagram showing ultrasound and PCR test findings for 22 infants with congenital CMV infectionThe red circles represent infants with apparent symptoms of congenital infection (symptomatic infection), and yellow circles represent infected infants without apparent symptoms (asymptomatic infection). Of 22 subjects with congenital infection, 11 with ultrasound fetal abnormalities were symptomatic. 11 subjects tested positive in PCR tests for the uterine cervical secretions, and 6 of them had no ultrasound findings were all asymptomatic. For 5 subjects with congenital infection had neither ultrasound findings nor positive PCR results, so caution is necessary.Journal informationTitle“Prediction of congenital cytomegalovirus infection in high-risk pregnant women”DOI10.1093/cid/ciw707AuthorsKenji Tanimura, Shinya Tairaku, Yasuhiko Ebina, Ichiro Morioka, Satoshi Nagamata, Kana Deguchi, Mayumi Morizane, Masashi Deguchi, Toshio Minematsu, and Hideto YamadaJournalClinical Infectious DiseasesResearchersYamada HidetoGraduate School of MedicineTanimura KenjiProfessorGraduate School of MedicineMorioka IchirouGraduate School of MedicineEbina YasuhikoGraduate School of MedicineNAGAMATA SatoshiAssistant ProfessorGraduate School of Medicine森實 真由美Graduate School of MedicineDeguchi MasashiProfessorGraduate School of MedicineSDGs)">Graduate School of MedicineHospitalSHAREMore from these researchersPress releases2023.08.25Medicine, dentistry and pharmacologyNovel autoantibodies are implicated in hypertensive disorders of pregnancy, fetal growth restriction, and other pregnancy disordersPress releases2021.01.27Medicine, dentistry and pharmacologyFetal and neonatal therapies improve prognosis of congenital cytomegalovirus infectionPress releases2020.12.22Medicine, dentistry and pharmacologyMaternal Immune Activation Induces Sustained Changes in Fetal Microglia MotilityPress releases2020.07.21Medicine, dentistry and pharmacologyDiscovery of novel autoantibody that is a major risk factor for recurrent pregnancy lossMore about these topicsPress releases2020.02.28Medicine, dentistry and pharmacologyClinical factors during pregnancy related to congenital cytomegalovirus infectionPress releases2017.07.21Medicine, dentistry and pharmacologyIssues with maternal screening for congenital cytomegalovirus infectionPress releases2018.05.31Medicine, dentistry and pharmacologyNext-generation sequencing sheds light on rotavirus in IndonesiaPress releases2016.04.01Medicine, dentistry and pharmacologyNew method proposed to detect bacterial infection in preterm infantsページの先頭へ1-1, Rokkodai-cho, Nada-ku, Kobe, 657-8501, JAPANProspective studentsCurrent studentsAlumsCorporate and societyFaculty and staffContactAccessJobsOfficial social media accountsCampus calendarPrivacy policySite policySite map© Kobe University