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--> Visit Contact JP EN About Message from the Director History Organization Chart Past Directors Archives Publications Outreach BRI VIDEOS Departments Brain Tumor Biology Cellular Neuropathology System Pathology for Neurological Disorders/Tainaka Lab System Pathology for Neurological Disorders/Ueno Lab System Pathology for Neurological Disorders/Laboratory for Evolutionary Brain Pathology Pathology Molecular Pathology (Visiting Professor Program) Neurosurgery Neurology Center for Integrated Human Brain Science Integrated Neuroscience Biological Magnetic Resonance Functional Neurology & Neurosurgery Center for Bioresource-based Researches Molecular Genetics Comparative & Experimental Medicine Animal Model Development Pathology Neuroscience Molecular Neuroscience Neuroscience of Disease/Matsui Lab Neuroscience of Disease/Sugie Lab Endowed Research Branch Advanced Treatment of Neurological Diseases Branch Research Research Findings Research Projects Global Partnerships Young Scientists at BRI Female Scientists at BRI Interview Medical Practice Graduate Degrees Graduate Programs Why study at BRI Student life at BRI Careers after BRI Joint Research Joint Usage / Research Research Equipment & Resources Data & Archives How to Apply for the BRI Global Collaborative Research Events Home> Departments> System Pathology for Neurological Disorders -Ueno Lab Basic Neuroscience BranchDepartment of System Pathology for Neurological Disorders -Ueno Lab Ueno Lab Website Members Prof. Masaki UENO Assist. Prof. Tokiharu SATO Assist. Prof. Takahiro INOUE Research Focus Central nervous system injuries due to stroke or trauma disrupt neural circuits and result in severe deficits of functions. The brain and spinal cord have very limited capacity to reconstruct the circuit once it is damaged, and therefore none of effective therapeutic methods have been developed so far. We previously demonstrated that spared motor and autonomic circuits are dynamically reorganized after injuries and influence the recovery process of functions. These results suggest that controlling the rewiring of the circuit would lead to make proper neuronal connections that achieve functional recovery. The goal of our study is to understand the process of rewiring and its underlying molecular mechanisms and neural functions. Toward this aim, we are analyzing neural systems of both normal and injured brain and spinal cord, using cutting-edge techniques including, mouse genetics, viral tracers, optogenetics, chemogenetics, and 3D behavior analysis. We believe that this study paves the way to develop novel strategies to regenerate circuits and restore neural functions. About Departments Research Medical Practice Graduate Degrees Joint Research Center Events Visit About This Website Links Sitemap Copyright © 2023 Brain Research Institute, Niigata University. All rights reserved.